Context Sensitive Half Life . When we first start an infusion, the plasma and tissue concentrations are both zero. It is a useful concept because it helps explain the duration of action of a drug given by infusion after stopping the infusion.
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Metabolism is by hepatic conjugation with renal excretion of inactive metabolites. This post discusses where these numbers come from. The graph comes from a paper by hughes et al in 1992.
Opioid Pharmacology
All the textbooks show the same graph for csht of anaesthetic drugs. The 80% decrement times of both sevoflurane and desflurane are also small (<8 min) and. Context sensitive half time (csht) is a very important concept, and one which you should be prepared to discuss at length. · time taken for plasma concentration c > c/2 as a function of duration of infusion.
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The 80% decrement times of both sevoflurane and desflurane are also small (<8 min) and. · time taken for plasma concentration c > c/2 as a function of duration of infusion. A constant plasma concentration) has been stopped. Trugreen hero commercial (:90) watch later. First of all, if you take a look at the two graphs above, you can see.
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Propofol is distributed rapidly and induces sedation within 30 to 60 seconds. The graph comes from a paper by hughes et al in 1992. This post discusses where these numbers come from. Bmay increase dose to extend dosing interval; When we first start an infusion, the plasma and tissue concentrations are both zero.
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Context sensitive half time (csht) is a very important concept, and one which you should be prepared to discuss at length. · not fixed but dependent on duration of infusion. · approaches but in theory does not reach t1/2β. The graph comes from a paper by hughes et al in 1992. Metabolism is by hepatic conjugation with renal excretion of.
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First of all, if you take a look at the two graphs above, you can see that propofol and ketamine have similar context sensitive half time. The half time will usually alter in the setting of varying durations of drug infusion Starts to reduce eeg activity in 20 seconds, peak effect in 90 seconds. Context sensitive half time (csht) is.
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Cequianalgesic dosing tables may underestimate the potency of methadone. The graph comes from a paper by hughes et al in 1992. Note that fentanyl’s context sensitive halftime increases significantly after 1hr of infusion. First of all, if you take a look at the two graphs above, you can see that propofol and ketamine have similar context sensitive half time. Metabolism.
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Note that fentanyl’s context sensitive halftime increases significantly after 1hr of infusion. Starts to reduce eeg activity in 20 seconds, peak effect in 90 seconds. · time taken for plasma concentration c > c/2 as a function of duration of infusion. Published online by cambridge university press: Bmay increase dose to extend dosing interval;
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This post discusses where these numbers come from. · approaches but in theory does not reach t1/2β. If the surgery is over 6 hours, stopping the infusion 40 minutes prior the. It is a useful concept because it helps explain the duration of action of a drug given by infusion after stopping the infusion. Note that fentanyl’s context sensitive halftime.
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Metabolism is by hepatic conjugation with renal excretion of inactive metabolites. · approaches but in theory does not reach t1/2β. First of all, if you take a look at the two graphs above, you can see that propofol and ketamine have similar context sensitive half time. The context is the duration of infusion. A constant plasma concentration) has been stopped.
